Current Issue : July - September Volume : 2019 Issue Number : 3 Articles : 5 Articles
Selective laser sintering (SLS) is a single-step three-dimensional printing (3DP) process that\ncan be leveraged to engineer a wide array of drug delivery systems. The aim of this work was to\nutilise SLS 3DP, for the first time, to produce small oral dosage forms with modified release properties.\nAs such, paracetamol-loaded 3D printed multiparticulates, termed miniprintlets, were fabricated\nin 1 mm and 2 mm diameters. Despite their large surface area compared with a conventional\nmonolithic tablet, the ethyl cellulose-based miniprintlets exhibited prolonged drug release patterns.\nThe possibility of producing miniprintlets combining two drugs, namely paracetamol and ibuprofen,\nwas also investigated. By varying the polymer, the dual miniprintlets were programmed to achieve\ncustomised drug release patterns, whereby one drug was released immediately from a Kollicoat\nInstant Release matrix, whilst the effect of the second drug was sustained over an extended time\nspan using ethyl cellulose. Herein, this work has highlighted the versatility of SLS 3DP to fabricate\nsmall and intricate formulations containing multiple active pharmaceutical ingredients with distinct\nrelease properties....
Thiocolchicoside is a semi synthetic drug derived from colchicoside used as a muscle relaxant as well as an anti-inflammatory agent. It has high aqueous solubility and low bioavailability. Hence, the aim of this study was to prolong the release of thiocolchicoside by developing polymeric microspheres. Microspheres were produced by ionotropic gelation technique to prolong the release of thiocolchicoside. Formulations were characterized for particle size and shape, surface morphology, entrapment efficiency and in-vitro drug release. The optimized formulation showed 60.6% entrapment efficiency and 83.18% drug release which was matched with predicted results given by statistical analysis of ANOVA. The microspheres had a porous surface and were found to be discreet and spherical in shape. The particles were heterogeneous with the maximum particles of an average size of 1.112 µm. Fourier transform-infrared spectral analysis and differential scanning calorimetry concluded the absence of any interaction between the drug and the excipients....
This paper introduces a new fibrous system for synergistic cancer therapy, which consists\nof gold nanocage (AuNC)-loaded poly caprolactone (PCL) fibers with encapsulation of a\nchemotherapeutic anticancer drug in their core and loading of a phase-changeable fatty acid in their\nsheath. Under on-off switching of near-infrared (NIR) light irradiation, the excellent photothermal\nability and photostability of AuNCs allows repeated, significant heating of the fibers to a temperature\navailable to hyperthermia. Simultaneously, the NIR light-induced heat generation enables the\nmelting out of the loaded fatty acid, leading to a rapid release of the drug molecules from the fibers.\nThe combination of this NIR light-triggered drug release with the repeated hyperthermia treatment\nexhibits excellent anticancer efficacy...
In recent years, different processing technologies have been engineered to fabricate\ncapsules or particles with peculiar properties (e.g., swelling, pH-sensitive response) at the micro\nand sub-micrometric size scale, to be used as carriers for controlled drug and molecular\nrelease. Herein, the development of cellulose acetate (CA) micro-carriers with mono- (MC)\nor bi-phasic (BC) composition is proposed, fabricated via electrohydrodynamic atomization\n(EHDA)- an electro-dropping technology able to micro-size polymer solution by the application of\nhigh voltage electrostatic forces. Image analysis allows identification of the process parameters to\noptimize morphology, in terms of size distribution and shape. Meanwhile, an accurate rheological\nstudy has enabled investigating the interface between CA solutions with different viscosities to\noptimize BC systems. Release tests have confirmed that BC carriers can retain the drug more efficiently\nin acidic conditions, also providing a more gradual and sustained release until six days, with respect\nto MC carriers. Hence, all these results have proven that biphasic architecture significantly improves\nthe capability of CA microcarriers to release ketoprofen lysinate, thus suggesting a new route to\ndesign core/shell systems for the retarded oral administration of anti-inflammatory drugs....
Cefepime is an antibiotic with a broad spectrum of antimicrobial activity. However, this antibiotic\nhas several side effects and a high degradation rate. For this reason, the preparation and characterization\nof new liposomes that are able to encapsulate this antibiotic seem to be an important research line in the\npharmaceutical industry. Anionic and cationic liposomes were prepared and characterized. All cationic\nstructures contained the same cationic surfactant, N,N,N-triethyl-N-(12-naphthoxydodecyl)ammonium.\nResults showed a better encapsulation-efficiency percentage (EE%) of cefepime in liposomes with\nphosphatidylcholine and cholesterol than with 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE).\nThe presence of cholesterol and the quantity of egg-yolk phospholipid in the liposome increased the\nencapsulation percentage. The bactericidal activity against Escherichia coli of cefepime loaded into liposomes\nwith phosphatidylcholine was measured. The inhibitory zone in an agar plate for free cefepime was similar\nto that obtained for loaded cefepime. The growth-rate constant of E. coli culture was also measured in\nworking conditions. The liposome without any antibiotic exerted no influence in such a rate constant. All\nobtained results suggest that PC:CH:12NBr liposomes are biocompatible nanocarriers of cefepime that can\nbe used in bacterial infections against Escherichia coli with high inhibitory activity....
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